https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Role of genetic susceptibility variants in predicting clinical course in multiple sclerosis: a cohort study https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:29865 Wed 24 Jun 2020 12:59:16 AEST ]]> Sun exposure across the life course significantly modulates early multiple sclerosis clinical course https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:47544 Wed 22 Mar 2023 15:52:30 AEDT ]]> Should there be a standardised approach to the diagnostic workup of suspected adult encephalitis? A case series from Australia https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:9232 Wed 11 Apr 2018 13:10:28 AEST ]]> Etiology of encephalitis in Australia, 1990-2007 https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:6867 Wed 11 Apr 2018 09:43:21 AEST ]]> Encephalitis in Australia, 1979-2006: trends and aetiologies https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:6864 Wed 11 Apr 2018 09:17:29 AEST ]]> STROKOG (stroke and cognition consortium): an international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:34396 Wed 09 Mar 2022 16:03:27 AEDT ]]> Variation within MBP gene predicts disease course in multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:34728 interaction = 0.05) and relapse (pinteraction = 0.02). Functional prediction analysis showed this variant is the target of many transcription factors and the binding sites of miR-218 and miR-188-3p. Conclusions: Our results provide novel insights into the role of genetic variation within the MBP gene predicting MS clinical course, both directly and by interaction with known environmental MS risk factors.]]> Wed 04 Sep 2019 10:04:21 AEST ]]> Common genetic variation within miR-146a predicts disease onset and relapse in multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:43091 Tue 13 Sep 2022 12:26:49 AEST ]]> Midsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: a multicentre Australian cohort study https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:34120 Tue 12 Feb 2019 13:13:57 AEDT ]]> Onset symptoms, Tobacco smoking, and progressive-onset phenotype are associated with a delayed onset of multiple sclerosis, and marijuana use with an earlier onset https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:43333 Thu 15 Sep 2022 14:57:26 AEST ]]> Associations between silicone skin cast score, cumulative sun exposure, and other factors in the Ausimmune study: a multicenter Australian study https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:7617 10 sunburns ever compared with no sunburns ever). Silicone casts of the dorsum of the hand provide a measure of cumulative UVR dose and number of sunburns over the lifetime, which persists after adjustment for chronological age. They can be used as an objective measure of cumulative past sun exposure in epidemiologic studies, but other determinants of skin damage, such as skin pigmentation, should be concurrently evaluated.]]> Sat 24 Mar 2018 08:34:44 AEDT ]]> Latitudinal variation in incidence and type of first central nervous system demyelinating events https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:10630 Sat 24 Mar 2018 08:13:48 AEDT ]]> Anthocyanins attenuate vascular and inflammatory responses to a high fat high energy meal challenge in overweight older adults: A cross-over, randomized, double-blind clinical trial https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:42832 2 SD 3.9) participated in a crossover, randomized, controlled, double-blind clinical trial (registered under Australian New Zealand Clinical Trials Registry, identifier no. ACTRN12620000437965). Participants consumed a HFHE meal with a 250 mL dose of either intervention (anthocyanins-rich Queen Garnet Plum) or control (apricot) juice. Blood samples and blood pressure measures were collected at baseline, 2 h and 4 h following the HFHE meal. Vascular and microvascular function were evaluated at baseline and 2 h after the HFHE meal. Results: Participants had a higher 2 h postprandial flow-mediated dilatation (+1.14%) and a higher microvascular post-occlusive reactive hyperaemia (+0.10 perfusion units per mmHg) when allocated to the anthocyanin compared to the control arm (P = 0.019 and P = 0.049, respectively). C-reactive protein was lower 4 h postprandially in the anthocyanins (1.80 mg/L, IQR 0.90) vs control arm (2.30 mg/L, IQR 1.95) (P = 0.026), accompanied by a trend for lower concentrations of interleukin-6 (P = 0.075). No significant postprandial differences were observed between treatments for blood pressure, triacylglycerol, total cholesterol, serum derivatives of reactive oxidative metabolites, tumor necrosis factor alpha, interleukin-1 beta, or maximum microvascular perfusion following iontophoresis of acetylcholine. Conclusion: Fruit-based anthocyanins attenuated the potential postprandial detrimental effects of a HFHE challenge on parameters of vascular and microvascular function, and inflammatory biomarkers in overweight older adults. Anthocyanins may reduce cardiovascular risk associated with endothelial dysfunction and inflammatory responses to a typical high fat 'Western' meal. Further studies are required to better elucidate the clinical implications of postprandial biomarkers of CVD.]]> Mon 05 Sep 2022 12:31:21 AEST ]]>